Over the past three decades, Indian enterprises have invested approximately USD 350– 400 billion cumulatively in foreign enterprise software platforms (ERP, CRM, PLM, CAD, MES, SCM, HRM). This research quantifies the long-term economic implications of this dependence using Total Cost of Ownership (TCO) models, capital outflow calculations, counterfactual net present value (NPV) analysis, and vendor lock-in quantification. Annual capital outflows to foreign software corporations total USD 8–12 billion, representing a cumulative transfer of USD 120–150 billion over 30 years. The opportunity cost analysis reveals that a USD 5–8 billion indigenous ERP platform investment could have generated USD 50–80 billion in export revenues and 24–36x return on investment. Vendor concentration in software markets (HHI > 2,500 in most categories) creates systemic vulnerability and estimated USD 37.8 billion in unnecessary lock-in costs over 20-year system lifecycles. The analysis demonstrates that India's continued dependence on foreign software represents one of the largest unrealized economic opportunities in the technology sector, with potential GDP impacts exceeding USD 75–135 billion if redirected toward indigenous platform development.